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Third Seal - Revelation 6:5
When He broke the third seal, I heard the third living creature saying, "Come." I looked, and behold, a black horse; and he who sat on it had a pair of scales in his hand.
And I heard something like a voice in the center of the four living creatures saying, "A quart of wheat for a denarius, and three quarts of barley for a denarius; and do not damage the oil and the wine."

Inflation due to shortages, supply and demand. Famines? Droughts?

Time frame would be around the 13th Century, give or take a hundred years. The duration of which is not given in the prophecy.

Some references are given to these cataclysmic events as happening around 13th century, with tree rings showing evidence. The climate changed radically causing lack of rainfall etc…

One Author has a book called The Little Ice Age How Climate Made History 1300 1850
Currently however, it is not as important in this chain of events, as the other events fit the time line sequence, and this famine event in itself is seen to have happened.

References:

http://www.geol.vt.edu/profs/jas/3114-web/00ElNino/990520-WP_Extreme.html

http://hallsciences.com/store/books_0465022723_The-Little-Ice-Age-How-Climate-Made-History-1300-1850.html